Promoter for neuropeptide FF and use thereof for therapy and diagnostics
OwnerPertti Aarre Juhani Panula, Annika Brandt +1inventors
InventorsPertti Aarre Juhani Panula, Annika Brandt, Johanna Westerlund
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Abstract
The present invention relates to isolating, sequencing and cloning of the 5′-flanking region of neuropeptide FF (NPFF) promoter. The characterized neuropeptide FF (NPFF) promoter is useful in gene therapy and in DNA analyses, and in production of gene-modified animals.
Claims26
A promoter for a neuropeptide FF gene comprising a promoter-active DNA fragment located in the 5′-flanking region of the neuropeptide FF gene, wherein said promoter-active DNA comprises nucleic acid selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:6;
- SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9.
A promoter for a neuropeptide FF gene comprising promoter-active DNA fragments located within nucleotide position 1 to position 2480 of SEQ ID NO:3.
A composition, comprising a coding region operationally coupled to a promoter and an acceptable carrier, wherein said promoter comprises promoter-active DNA fragments which are located in the 5′-flanking region of the human neuropeptide FF gene, wherein said promoter-active DNA comprises SEQ ID NO:3.
A promoter for a neuropeptide FF gene comprising promoter-active DNA fragments located within nucleotide position 1 to position 9840 of SEQ ID NO:1.
A composition, comprising a coding region operationally coupled to a promoter and an acceptable carrier, wherein said promoter comprises promoter-active DNA fragments which are located in the 5′-flanking region of the mouse neuropeptide FF gene, wherein said promoter-active DNA is selected from the group consisting of bases 9516-9840 of SEQ ID NO:1, SEQ ID NO:6 and SEQ ID NO:7.
A nucleic acid comprising nuclcotides 9516-9840 of SEQ ID NO:1.
A nucleic acid comprising nucleotides 1-399 of SEQ ID NO:7.
A nucleic acid comprising nucleotides 1-398 of SEQ ID NO:8.
A nucleic acid comprising nucleotides 1-399 of SEQ ID NO:9.
A nucleic acid comprising SEQ ID NO:6.
A nucleic acid comprising SEQ ID NO:3.
Dependencies are inferred from the claim text.