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AssigneesJapan AS Represented By Director General of National Institute of Health Sciences, Juridical Foundation, Japanese Foundation for Cancer Research
InventorsTohru Masui, Satoshi Yamaguchi
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The present invention relates to a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 or consisting of an amino acid sequence wherein one or more amino acids are deleted, replaced or added in the amino acid sequence of SEQ ID NO:1 and having cell growth inhibitory activity; DNA coding for the polypeptide; DNA hybridizing with DNA consisting of the nucleotide sequence of SEQ ID NO: 1 or 2 or with an oligonucleotide probe prepared based on the nucleotide sequence; a recombinant vector comprising the DNA; a transformant obtained by introducing the recombinant vector into host cells; a process for producing the polypeptide by culturing the transformant of the present invention in a medium; a pharmaceutical composition, preferably an anti-tumor agent, comprising the polypeptide as an active ingredient; a method of preventing or treating tumors comprising administering an effective amount of the polypeptide; and use of the polypeptide for producing a pharmaceutical composition useful for preventing or treating tumors.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence of SEQ ID No. 5, said polypeptide having an activity of inhibiting growth of tumor cells.
An isolated DNA which hybridizus at 42° C. with DNA consisting of the nucleotide sequence of SEQ ID NO:
An isolated DNA which hybridizes at 42° C. with DNA consisting of the nucleotide sequence of SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence of SEQ ID NO. 5, wherein said polypeptide has any 85 to 309 consecutive amino acid sequence of SEQ ID NO. 10, said polypeptide having an activity of inhibiting growth of tumor cells.
Dependencies are inferred from the claim text.