Linear polyamine compounds and polyamine based anti-tumor agents
AssigneeRiken
InventorMasaaki Iwata
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Abstract
Nobel polyamine compounds and polyamine compounds having carcinostatic action are provided. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula (I) or (III) and/or pharmaceutically acceptable salts thereof. Specifically, there are provided anticancer agents containing as active ingredient at least one of 1,18-bis(ethylamino)-5,14-diazaoctadecane, 1,16-bis(cyclopropylmethylamino)-5,12-diazahexadecane, 1,17-bis(cyclopropylmethylamino)-5,13-diazaheptadecane and/or pharmaceutically acceptable salts thereof.
Claims7
A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof
- wherein:
- n is an integer of 1-8,
- R1 represents a hydrogen atom or a p-toluenesulfonyl group,
- R2 represents a group represented by the following Formula (II),
- R3 represents a hydrogen atom or a p-toluenesulfonyl group, and
- R4 represents a group represented by the following Formula (II):
- where m is 1 or 2,
- R5 represents a hydrogen atom or a p-toluenesulfonyl group, and
- R6 represents a cyclopropylmethyl group.
An anticancer agent, which contains, as an active ingredient, 1,1 6-bis(cyclopropyl-methylamino)-5,12-diazaliexadecane and/or a pharmaceutically acceptable salt thereof.
An anticancer agent which contains, as an active ingredient, 1,17-bis(cyclopropylmethylamino)-5,13-diazaheptadecane and/or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.