Compositions and methods for reversibly increasing permeability of biomembranes

A method of reversibility permeabilizing a biological membrane comprising exposing the membrane to a compound of the general formula II.

A method of reversibility permeabilizing a biological membrane comprising exposing the membrane to a compound of the general formula III.

A method of reversibly permeabilizing a biological membrane which comprises administering to a mammal a compound of the general formula II.

A method of reversibly permeabilizing a biological membrane which comprises administering to a mammal a compound of the general formula III.

A method of treating CNS lesions or diseases comprising:

• administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically effective amount of a compound of the general formula II or III as heretofore defined;
• and subsequently administering a therapeutic agent within 24 hours.

A method of enhancing permeabilization of a biological membrane comprising exposing the membrane to a compound of the general formula II:

• wherein R denotes a saturated or unsaturated chain of between 1 to 10 carbon atoms and R′ denotes a saturated or unsaturated chain of between 5 and 30 carbon atoms, their salts, esters and amides.

A method of improving CNS imaging comprising:

• administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically effective amount of a compound of the general formula II or III as heretofore defined;
• and subsequently administering a therapeutic agent within 24 hours.

A pharmaceutical composition for the permeabilization of biological membranes comprising a compound of the general formula:

• wherein R denotes an unsaturated chain of between 4 to 10 carbon atoms and R′ denotes a saturated or unsaturated chain of between 5 and 30 carbon atoms, their salts, esters and amides;
• and,
• at least one pharmaceutically acceptable carrier.

A pharmaceutical composition for the permeabilization of biological membranes comprising a compound of the general formula:

• wherein R denotes a saturated chain of between 4 to 10 carbon atoms and R′ denotes an unsaturated chain of between 5 and 30 carbon atoms, their salts, esters and amides;
• and,
• at least one pharmaceutically acceptable carrier.

A pharmaceutical composition for the permeabilization of biological membranes comprising a compound of the general formula:

• wherein R denotes a saturated chain of between 4 to 10 carbon atoms and R′ denotes a saturated chain of between 25 and 30 carbon atoms, their salts, esters and amides;
• and,
• at least one pharmaceutically acceptable carrier.