US 6,319,950 B1 · Suppression of carcinoma using high purity conjugated linoleic acid (CLA)

Abstract

A method for the treatment of carcinoma in a human is disclosed, including administering to a human a therapeutically effective amount of 9-cis, 11-trans octadecadienoic acid formed by reacting an ester of ricinoleic acid with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of an ester of ricinoleic acid, and reacting the tosylate or mesylate of an ester of ricinoleic acid with diazabicyclo-undecene. The method includes administering to a human a purified conjugated linoleic acid (CLA) produced by a novel synthesis process for producing 9-cis, 11-trans octadecadienoic acid at room temperature in high yield including providing a tosylate or mesylate of a methyl ester of ricinoleic acid and providing a purified 9-cis, 11-trans octadecadienoic acid formed when the tosylate or mesylate reacts with diazabicyclo-undecene.

Claims20

Dependent claims

A method for the treatment of carcinoma in a human, comprising:

administering to a human a therapeutically effective amount of 9-cis, 11-trans octadecadienoic acid formed by reacting an ester of ricinoleic acid with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of an ester of ricinoleic acid, and reacting said tosylate or mesylate of an ester of ricinoleic acid with diazabicyclo-undecene.

Dependencies are inferred from the claim text.

Facts

Application

09/283,042Filed 1 Apr 1999 · continuation in part

Priority

18 Feb 1997

Granted

20 Nov 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/231
Of acids having a carboxyl group bound to a chain of seven or more carbon atoms: having one or two double bonds
C07C 51/377
By reactions not involving formation of carboxyl groups: by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
C07C 51/42
Preparation of carboxylic acids or their salts, halides or anhydrides: separation; Purification; Stabilisation; Use of additives
C07C 303/28
Of esters of sulfonic acids: by reaction of hydroxy compounds with sulfonic acids or derivatives thereof

Suppression of carcinoma using high purity conjugated linoleic acid (CLA)

Life of this patent

Suppression of carcinoma using high purity conjugated linoleic acid (CLA)

Life of this patent

Abstract

Claims20