Oral formulation for paclitaxel
AssigneeSuperGen, Inc.
InventorsRajashree Joshi, Ashok Y. Gore, Joseph Rubinfeld, Rajesh Shrotriya
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Abstract
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharrnaceutically-acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structures R1COOR2, R1CONR2, and R1COR2, wherein R1 is a hydrophobic C3-C50 alkane, alkene or alkyne and R2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6.
Claims23
A composition suitable for orally administering paclitaxel comprising:
- paclitaxel;
- and
- a pharmaceutically-acceptable, water-miscible solubilizer selected from the group consisting of solubilizers having the general structures
- R1COOR2, R1CONR2, and R1COR2,
- wherein R1is a derivative of d-α-tocopherol and R2 is a hydrophilic moiety.
A method for orally administering paclitaxel to a host in need thereof comprising:
- providing a pharmaceutical composition comprising paclitaxel and a pharmaceutically-acceptable, water-miscible solubilizer selected from the group consisting of solubilizers having the general structures
- R1COOR2, R1CONR2, and R1COR2,
- wherein R1 is a derivative of d-α-tocopherol and R2 is a hydrophilic moiety;
- and
- orally administering the pharmaceutical composition in a therapeutically effective amount to the host in need thereof.
Dependencies are inferred from the claim text.