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US 6,319,933 B1Granted
Azole derivatives
AssigneeBasilea Pharmaceutica AG
InventorsSusumu Komiyama, Nobuo Shimma, Takuo Tsukuda
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Abstract
The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the same as defined in the claims and the description. 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the present invention have antifungal activity and are useful for the treatment of fungal diseases.
Claims15
A compound of the formula,
- wherein
- Q is a phenyl ring which is unsubstituted or substituted by 1 to 3 halogen atom(s);
- R is hydrogen, hydroxy, carboxy, carbamoyl, cyano, lower-alkyl, lower-alkoxycarbonyl or lower-alkoxy, wherein said lower-alkyl, lower-alkoxycarbonyl and lower-alkoxy is unsubstitued or substituted by one or more halogen, lower-alkyl, di-lower-alkylamino or lower-alkoxy;
- X is a 5 or 6 membered hetero-aromatic ring;
- Y is phenyl or pyridyl, each of which is unsubstitued or substituted by one or more halogen, cyano, lower-alkyl, di-lower-alkylamino, lower-alkyloxy, acyl, lower-alkoxycarbonyl;
- and
- Z is a sulfur and nitrogen containing 5 membered hetero-aromatic ring;
- or pharmaceutically acceptable salts thereof.
5 more elements
Dependencies are inferred from the claim text.