Substituted dimeric compounds

A compound selected from those of formula (I):

• A—G1—Cy—G2—Cy—G3—B (I)
• wherein:
• A represents a grouping of formula
• wherein:
• Q represents sulphur or oxygen,
• R1, R2 and R3, which may be identical or different, represent hydrogen or Ra (wherein Ra represents unsubstituted or substituted linear or branched (C1-C6)alkyl, unsubstituted or substituted linear or branched (C2-C6)alkenyl, unsubstituted or substituted linear or branched (C2-C6)alkynyl, unsubstituted or substituted (C3-C8)-cycloalkyl, unsubstituted or substituted cycloalkyl-(C3-C8)alkyl (C1-C6) in which the alkyl moiety is linear or branched, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, aryl, aryl(C1-C6)alkyl in which the alkyl moiety is linear or branched, aryl(C2-C6)alkenyl in which the alkenyl moiety is linear or branched, heteroaryl, heteroaryl(C1-C6)alkyl in which the alkyl moiety is linear or branched, or heteroaryl(C2-C6)alkenyl in which the alkenyl moiety is linear or branched),
• or R2 and R3 form, with the nitrogen atom carrying them, a group selected from piperazinyl, piperidinyl, and pyrrolidinyl,
• B represents a grouping of formula
• or
• —NR2R3, wherein Q, R1, R2 and R3 are as defined hereinbefore,
• G1 and G3, which may be identical or different, represent a linear or branched alkylene chain having 1 to 4 carbon atoms that is optionally substituted by one or more identical or different groups selected from hydroxy, carboxy, formyl, Ra, ORa, COORa and CORa (wherein Ra is as defined hereinbefore),
• Cy represents
• a ring structure of formula (II):
• wherein:
• X and Y, which may be identical or different, represent sulphur, oxygen, carbon, or CH, or CH2,
• R4 represents hydrogen, halogen, CF3, hydroxy, carboxy, formyl, amino, NHRa, NRaR1a, NHCORa, CONHRa, Ra, ORa, CORa, or COORa (wherein Ra is as defined hereinbefore and R1a can have any of the meanings of Ra),
• the symbol — — — — means that the bonds are single or double, with the proviso that the valency of the atoms is respected,
• wherein G2 substitutes the benzene ring, and G1 (and G3 respectively) substitutes the ring containing X and Y,
• or Cy represents a ring structure of formula (III):
• wherein:
• Z represents sulphur, oxygen, CH, CH2, NH, NSO2Ph, or NRa (wherein Ra is as defined hereinbefore),
• D represents a benzene or pyridine ring,
• R4 is as defined hereinbefore,
• the symbol — — — — means that the bond is single or double, with the proviso that the valency of the atoms is respected,
• wherein G2 substitutes the D ring, and G1 (and G3 respectively) substitutes the ring containing Z,
• it being understood that the two rings (Cy) of the compounds of formula (I) represent the same basic ring structure (indole/indole, naphthalene/naphthalene, benzofuran/benzofuran, etc.), but that the substituent R4 may be different,
• G2 represents a chain of formula (IV):
• wherein:
• W1, W2 and W3, which may be identical or different, represent a bond, oxygen, sulphur, CH2, CHRa, NH, or NRa (wherein Ra is as defined hereinbefore),
• n represents 0≦n≦6,
• m represents 0≦m≦6,
• with the proviso that it is not possible to have two consecutive hetero atoms and that the chain of formula (IV) so defined may have one or more unsaturated bonds,
• wherein:
• the compound of formula (I) cannot represent diethyl 2-(acetylamino)-2-{[5-({3-[2-(acetylamino)-3-ethoxy-2-(ethoxycarbonyl)-3-oxopropyl]-1H-indol-5-yl}methyl)-1H-indol-3-yl]methyl}malonate,
• or N-{2-[5-({3-[2-(acetylamino)ethyl]-1H-indol-5-yl}methyl)-1H-indol-3-yl]-methyl}acetamide,
• “aryl” is understood to mean naphthyl, phenyl, or biphenyl,
• “heteroaryl” is understood to mean any saturated or unsaturated mono- or bi-cyclic group containing 5 to 10 atoms and containing 1 to 3 hetero atoms selected from nitrogen, sulphur, and oxygen,
• it being possible for “aryl” and “heteroaryl” to be substituted by one or more identical or different radicals selected from hydroxy, carboxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)alkyl, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, formyl, cyano, nitro, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• the term “substituted” applied to the terms “alkyl”, “alkenyl”, and “alkynyl” means that those groups are substituted by one or more identical or different
• radicals selected from hydroxy, linear or branched (C1-C6)alkoxy, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• the term “substituted” applied to the terms “cycloalkyl” and “cycloalkylalkyl” means that the cyclic moiety of those groups is substituted by one or more identical or different radicals selected from hydroxy, linear or branched (C1-C6)alkoxy, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically/acceptable acid or base.