Method of treating a tumor
AssigneeSanofi-Synthelabo
InventorsDaniel L. Dexter, Paul E. Juniewicz, James B. Rake, Daniel D. Von Hoff
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Abstract
In accordance with the present invention there is provided a method of treating a mammal having a solid tumor, the method comprising: a) administering to the mammal an effective amount of 3-ainino-1,2,4-benzotriazine 1,4-dioxide; b) administering to the mammal an effective amount of paclitaxel; and c) administering to the mammal an effective amount of a platinum complex. The method provides unexpected synergistic efficacy. The invention further provides a kit for treatment of a mammalian tumor comprising 3-amino-1,2,-benzotriazine 1,4-dioxide, paclitaxel and a platinum complex.
Claims7
A method of treating a mammal having a solid tumor, said method comprising administering to said mammal a synergistically effective amount of 3-amino-1,2,4-benzotriazine 1,4-dioxide;
- paclitaxel;
- and
- a platinum complex selected from the group consisting of cisplatin and carboplatin.
A kit for treatment of a mammalin tumor comprising a synergistically effective amount of 3-amino-1,2,4-benzotriazine 1,4-dioxide, paclitaxel and a platinum complex selected from the group consisting of oxaliplatin, cisplatin and carboplatin.
Dependencies are inferred from the claim text.