Cytoprotective effect of polycyclic phenolic compounds
AssigneesApollo BioPharmaceuticals, Inc., University of Florida Research Foundation, Inc.
InventorsJames W. Simpkins, Katherine D. Gordon, Pattie S. Green
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Abstract
The invention comprises methods for conferring a cytoprotective effect on a population of cells, such as providing a polycyclic phenolic compound in a physiologically acceptable formulation, and administering the formulation in an effective dose to the population of cells.
Claims36
A method for conferring a cytoprotective effect on a population of cells, comprising:
- (a) providing a polycyclic phenolic compound in a physiologically acceptable formulation wherein the phenol in the compound is located at a terminal position such that the compound with the terminal phenol has a substantially enhanced cytoprotective effect in a cell based assay compared with the compound lacking the terminal phenol;
- and
- (b) administering the formulation in an effective dose to the population of cells to confer cytoprotection.
A method for conferring cytoprotection in a population of cells in a subject, comprising:
- (a) providing a polycyclic phenolic compound in a physiologically acceptable formulation wherein the phenol in the compound is located at a terminal position such that the compound with the terminal phenol has a substantially enhanced cytoprotective effect in a cell based assay compared with the compound lacking the terminal phenol;
- and
- (b) administering the formulation in an effective dose to the subject to confer cytoprotection.
A method for conferring a cytoprotective effect on a population of cells, comprising:
- (a) providing a polycyclic compound having a terminal phenolic ring, any of one, two or three additional ring structures, and a molecular weight in the range of 170-1000 daltons, in a physiologically acceptable formulation;
- and
- (b) administering the formulation in an effective dose to the population of cells to confer cytoprotection.
Dependencies are inferred from the claim text.