Penetration enhancing and irritation reducing systems
AssigneeCellegy Pharmaceuticals, Inc.
InventorsVivien H. W. Mak, Stephen Grayson
Life of this patent
Estimating the term…
Abstract
This invention lies in the technology of transdermal and topical drug delivery. In particular, the present invention relates to enhancement of the penetration of transdermally or topically applied drugs and with the reduction of skin irritation that often accompanies transdermal and topical drug delivery.
Claims26
A method for administering a topically or systemically active agent with increased penetration, said method comprising:
- topically administering to a mammal a composition comprising:
- a) an active agent having a concentration of about 0.1% to about 2%, wherein said active agent is a member selected from the group consisting of testosterone, estradiol, derivatives thereof and the mixture thereof;
- b) a penetration-enhancing system consisting essentially of (i) a membrane fluidizer comprising oleic acid;
- (ii) a C1-C4 alcohol;
- and (iii) a glycol said composition having a pH value of between about 4 to about 8, thereby administering a topically or systemically active agent with increased penetration.
A method for reducing inflammation associated with topical application of a topically or systemically active agent, said method comprising:
- topically administering to a mammal a composition comprising:
- a) an active agent having a concentration of about 0.1% to about 2%, wherein said active agent is a member selected from the group consisting of testosterone, estradiol, derivatives thereof and the mixture thereof;
- b) a penetration-enhancing system consisting essentially:
- (i) a membrane fluidizer comprising oleic acid;
- (ii) a C1-C4 alcohol;
- and (iii) a glycol said composition having a pH value of between about 4 to about 8, thereby reducing inflammation associated with a topical application of a topically or systemically active agent.
A method for administering a topically or systemically active agent with increased penetration, said method comprising:
- topically administering to a mammal a composition comprising:
- a) testosterone or a derivative thereof having a concentration of about 0.1% to about 2%;
- b) a penetration-enhancing system comprising:
- (i) oleic acid;
- (ii) a C3 alcohol;
- and (iii) propylene glycol thereby administering a topically or systemically active agent with increased penetration.
A method for administering a topically or systemically active agent with increased penetration, said method comprising:
- topically administering to a mammal a composition comprising:
- a) estradiol or a derivative thereof having a concentration of about 0.1% to about 10%;
- b) a penetration-enhancing system comprising:
- (i) oleic acid;
- (ii) a C3 alcohol;
- and (iii) propylene glycol, thereby administering a topically or systemically active agent with increased penetration.
Dependencies are inferred from the claim text.