Formulation comprising antibacterial substance and antiulcer substance

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of benzylpenicillin and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of piperacillin and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of mecillinam and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of cefixime and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of cefalcor and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.

A formulation for the use in treating a gastrointestinal ulcer in mammals which comprises (1) a synergistic effective amount of erythromycin and a pharmaceutically acceptable carrier thereof, and (2) about 1-95% by weight based on the weight of the set of an antiulcer substance comprising a benzimidazole compound and a pharmaceutically acceptable carrier thereof, wherein the antibacterial substance is formulated into a gastrointestinal mucosa-adherent solid preparation, and wherein the ratio of the antibacterial substance to antiulcer substance is about 0.005 to 15 by weight.