Anticonvulsant derivatives useful in treating cluster headaches
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsEnrique J. Carrazana, Steve D. Wheeler
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Abstract
Anticonvulsant derivatives useful in treating cluster headaches are disclosed.
Claims15
A method for treating cluster headaches in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of the formula I:
- wherein
- X is oxygen;
- R1 is hydrogen or C1-C4 alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl;
- or
- R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II):
- wherein R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or
- R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.
A method of inducing cluster remission in a subject suffering from cluster headaches comprising administering to the subject a therapeutically effective amount of a compound of the formula I:
- wherein
- X is oxygen;
- R1 is hydrogen or C1-C4 alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl;
- or
- R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II):
- wherein R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or
- R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.
A method of reducing cluster period duration in a subject suffering from cluster headaches comprising administering to the subject a therapeutically effective amount of a compound of the formula I:
- wherein
- X is oxygen;
- R1 is hydrogen or C1-C4 alkyl;
- and
- R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl;
- or
- R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II):
- wherein R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or
- R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.
Dependencies are inferred from the claim text.