Raising blood sugar level in hypoglycemic mammals by administering inhibitors of dipeptidyl peptidase IV
AssigneeProbiodrug AG
InventorsHans-Ulrich Demuth, Torsten Hoffmann, Kerstin Kuhn-Wache, Fred Rosche
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Abstract
A method of raising the blood sugar level in a mammal having hypoglycemia is described. The method reduces degradation of glucagon by administering to the mammal a therapeutically effective amount of an inhibitor of dipeptidyl peptidase IV and physiologically acceptable adjuvants and/or excipients.
Claims4
A method of raising the blood sugar level in a mammal having hypoglycemia by reducing degradation of glucagon, said method comprising administering to said mammal a therapeutically effective amount of an inhibitor of dipeptidyl peptidase (DP IV) and physiologically acceptable adjuvants and/or excipients for reducing in said mammal activity of endogenous DP IV.
A method for stimulating endogenous glucose production via glucagon stabilization in a mammal having hypoglycemia comprising the step of administering, to said mammal a therapeutically effective amount of a dipeptidyl peptidase IV (DP IV) inhibitor and physiologically acceptable adjuvants and/or excipients for reducing in said mammal the enzymatic activity of endogenous DP IV to reduce degradation of glucagon.
Dependencies are inferred from the claim text.