Method of diagnosing and treating gliomas
OwnerHarald W. Sontheimer, Nicole Ullrichinventors
Life of this patent
Estimating the term…
Abstract
The present invention provides a recombinant toxin and monoclonal antibody which specifically binds to glial-derived or meningioma-derived tumor cells. Also provided are various methods of screening for malignant gliomas and meningiomas. Further provided are methods of treating malignant gliomas, including glioblastoma multiforme and astrocytomas.
Claims35
A method of treating a tumor expressing a glioma chloride channel in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin linked to a cytoxic agent.
A method of treating a tumor expressing a glioma chloride channel in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin fused to a second protein.
A method of treating a glioma in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin linked to a cytotoxic agent.
A method of treating a meningioma in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin linked to a cytotoxic agent.
A method of treating a glioma in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin fused to a second protein.
A method of treating a meningioma in a patient comprising administering an effective amount of a pharmaceutical composition comprising chlorotoxin fused to a second protein.
Dependencies are inferred from the claim text.