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AssigneeThe Trustees of Columbia University in the City of New York
InventorsMartin Chalfie, James J. Taub, Jonathan Rothblatt, Charles Ma, Jang-Hee Hahn
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This invention provides a composition comprising an amount of a polypeptide effective to increase the life-span of cells wherein the polypeptide has the amino acid sequence of a cytosolic catalase and a suitable carrier. This invention also provides an isolated nucleic acid molecule encoding a cytosolic catalase. This invention also provides a host vector system for the production of a polypeptide having the biological activity of catalase which comprises the above-described vectors in a suitable host. This invention also provides a method for prolonging cell life, comprising: (a) linking the above-described nucleic acids to a regulatory element such that the expression of the above-described nucleic acids is under the control of the regulatory element; and (b) introducing the linked nucleic acid into cells for expression of the nucleic acid, thereby prolonging cell life.
An isolated nucleic acid molecule encoding a ctl-1 cytosolic catalase.
A vector comprising a nucleic acid sequence encoding a ctl-1 cytosolic catalase.
A cell comprising an exogenous nucleic acid molecule encoding a ctl-1 cytosolic catalase.
A composition comprising (a) a nucleic acid molecule comprising a ctl-1 cytosolic catalase-encoding sequence which, when introduced into a cell, causes the expression of an amount of the ctl-1 cytosolic catalase sufficient to increase the life-span of the cell, and (b) a suitable carrier.
Dependencies are inferred from the claim text.