Nucleic acids encoding mutant human carboxypeptidase A enzymes
AssigneeGlaxo Wellcome Inc.
InventorsGary Keith Smith, Todd Andrew Blumenkopf, Michael Cory
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Abstract
The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.
Claims30
A nucleic acid molecule encoding a conjugate molecule comprising a cell targeting molecule and a mutant human carboxypeptidase A enzyme, wherein the enzyme possesses amino acid substitutions at one or more residues at positions corresponding to positions 203, 210, 242, 244, 250, 253, 255, 267, 268, 269, and 305 as set forth in SEQ ID NO:2.
An isolated nucleic acid molecule encoding a mutant human carboxypeptidase A enzyme, wherein the enzyme possesses amino acid substitutions at one or more residues at positions corresponding to positions 203, 210, 242, 244, 250, 253, 255, 267, 268, 269, and 305 as set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.