Asp2
AssigneeSmithKline Beecham Corporation
InventorsDavid J Powell, Conrad G Chapman, Kay Murphy, Trudi S Smith
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Abstract
ASP2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP2 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, cancer, and prohormone processing, among others, and diagnostic assays for such conditions.
Claims11
An isolated polynucleotide comprising a nucleotide sequence which, by virtue of degeneracy of the genetic code, encodes the amino acid sequence set forth in SEQ ID NO:2.
An isolated polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:
- 1.
An isolated polynucleotide consisting of the polynucleotide sequence set forth in SEQ ID NO:
- 1.
An expression vector comprising an isolated polynucleotide, wherein said expression vector produces an ASP2 polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2 when said expression vector is present in a compatible host cell.
An isolated polynucleotide that is fully complementary to a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence which, by virtue of degeneracy of the genetic code, encodes the amino acid sequence set forth in SEQ ID NO:2;
- (b) a nucleotide sequence comprising SEQ ID NO:1;
- and
- (c) a nucleotide sequence consisting of SEQ ID NO:1.
Dependencies are inferred from the claim text.