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US 6,319,683 B1Granted
Method and composition for controlling formaldehyde fixation by delayed quenching
AssigneeIntergen Company
InventorsWilliam M. James, Stephen W. Hoag
Life of this patent
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Abstract
A method and composition for quenching formaldehyde fixation of cell and tissue specimens. The composition includes a formaldehyde-reactive agent. The formaldehyde-reactive agent reacts with the formaldehyde to quench the fixation of the cell or tissue specimen. The method involves contacting a formaldehyde fixative solution with the composition.
Claims84
A composition comprising:
- (a) a first agent capable of chemically reacting with formaldehyde, and
- (b) a second agent capable of substantially preventing the first agent from chemically reacting with formaldehyde,
- wherein, if the composition is contacted with formaldehyde, then the second agent substantially prevents the first agent from chemically reacting with the formaldehyde for a finite period of time,
- wherein, after the finite period of time, the first agent chemically reacts with the formaldehyde,
- wherein, if 1.5 moles of the first agent and 1.0 moles of the formaldehyde are chemically reacted at 22° C., then the chemical reaction consumes at least about 90% of the formaldehyde within 20 minutes.
2 more elements
A composition comprising:
- (a) a first agent capable of chemically reacting with formaldehyde, and
- (b) a second agent capable of substantially preventing the first agent from chemically reacting with formaldehyde,
- wherein, if the composition is contacted with formaldehyde, then the second agent substantially prevents the first agent from chemically reacting with the formaldehyde for a finite period of time,
- wherein, after the finite period of time, the first agent chemically reacts with the formaldehyde,
- wherein, if 1.5 moles of the first agent and 1.0 moles of the formaldehyde are chemically reacted at 2° C., then the chemical reaction consumes at least about 90% of the formaldehyde within 120 minutes.
2 more elements
Dependencies are inferred from the claim text.