Microparticles of lactide-co-glycolide copolymers and methods of making and using the same
AssigneeUniversity Technology Corporation
InventorsTheodore W. Randolph, Corinne Lengsfeld, Richard Frank Falk, III
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Abstract
The present invention relates to the formation of microparticles from copolymers during a process involving precipitation with compressed antisolvents. The family of suitable copolymers have a semi-crystalline structure that above their glass transition temperature retain sufficient crystalline strength to form microparticles. The invention also provides systems comprising the microparticles encapsulated with a desired compound for the controlled release of the compound over a predetermined period of time.
Claims8
A method for making semi-crystalline copolymeric microparticles in a precipitation by compressed antisolvent (PCA) process, comprising the steps of:
- (a) providing a semi-crystalline copolymer;
- and
- (b) exposing said semi-crystalline copolymer to a compressed antisolvent at a temperature of about 35° C. and pressure of 3 to 9.5 MPa, to form said semi-crystalline copolymenric microparticles.
Dependencies are inferred from the claim text.