Acid salts of cholesterol
AssigneesThe University of Tennessee Research Corporation, McMaster University
InventorsLeaf Huang, Richard M. Epand, Remo Bottega
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Abstract
A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, and an appropriate co-lipid. The invention also includes the cationic lipids and mammalian plasmid DNA or other cells in admixture with the aqueous dispersion.
Claims9
A stable aqueous dispersion of mixed lipids which dispersion comprises a cationic lipid of a structure which comprises a lipophilic group derived from cholesterol, a linker bond selected from the group consisting of carboxy amide and carbamoyl, a spacer arm having from 1 to 20 carbon atoms in a branched or unbranched linear alkyl chain, and a cationic amino group selected from the group consisting of primary, secondary, tertiary and quaternary amino groups, and a co-lipid which is a neutral phospholipid.
An inorganic acid salt of 3β[N-(N1-N1-dimethylaminoethane) carbamoyl] cholesterol.
An organic solvent-free cationic lipid of a derivative of cholesterol, which is 3β[N-(N1-N1-dimethylaminoethane) carbamoyl] cholesterol.
Dependencies are inferred from the claim text.