US 6,319,515 B1 · Isosorbide dinitrate-containing patch

Abstract

The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B=70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.

Claims26

Dependent claims

An isosorbide dinitrate-containing patch, comprising:

(a) a flexible support;
and
(b) an adhesive layer formed on the flexible support, wherein the adhesive layer comprises an adhesive composition comprising:
(i) a (meth)acrylic acid alkyl ester-based adhesive (A);
(ii) a polyvinyl acetate-based adhesive (B), wherein adhesive (B) has a weight average molecular weight range of from 150,000 to 1,000,000;
(iii) a plasticizing component (C);
and
(iv) isosorbide dinitrate (D);
and the adhesive composition satisfies the following conditions (1) through (3):
(1) the weight of (A) to the weight of (B) is from 70:30 to 10:90;
(2) the weight ratio of (C) based on the weight of the adhesive composition is from 10 to 40%;
and
(3) the weight ratio of (D) based on the weight of the adhesive composition is from 20 to 35%.

10 more elements

A method for manufacturing an isosorbide dinitrate-containing patch, comprising:

(1) forming an adhesive layer, wherein the adhesive layer comprises at least two layers comprising:
(i) a reservoir layer arranged at a flexible support side of the patch;
and
(ii) an adhering releasing layer arranged at a human skin side of the patch, the reservoir layer having a thickness of 10 to 100 μm and comprising a first adhesive composition comprising:
(A) a (meth)acrylic acid alkyl ester-based adhesive;
(B) a polyvinyl acetate-based adhesive, wherein said polyvinyl acetate-based adhesive has a weight average molecular weight range of from 150,000 to 1,000,000;
(C) a plasticizing component;
and
(D) isosorbide dinitrate;
the first adhesive composition satisfying the following conditions (I) through (III):
(I) the weight of (A) to the weight of (B) is from 60:40 to 10:90;
(II) the weight ratio of (C) based on the weight of the first adhesive composition is 20 to 40%;
and
(III) the weight ratio of (D) based on the weight of the first adhesive composition is 22 to 45%,
and the adhering releasing layer having a thickness of 3 to 25 μm and comprising a second adhesive composition, the second adhesive composition comprising components (A), (B), (C), and (D) as defined above and satisfying the following conditions (I′) through (III′):
(I′) the weight of (A) to the weight of (B) is from 0:100 to 100:0;
(II′) the weight ratio of (C) based on the weight of the second adhesive composition is 0 to 40%;
and
(III′) the weight ratio of (D) based on the weight of the second adhesive composition is 0 to 30%, and
(2) laminating the adhesive layer to the flexible support, wherein the flexible support comprises a fabric having 5 to 60 g/m2 unit area weight.

17 more elements

Dependencies are inferred from the claim text.

Isosorbide dinitrate-containing patch

Life of this patent

Isosorbide dinitrate-containing patch

Life of this patent

Abstract

Claims26