Analgesic and anti-inflammatory compositions comprising domperidone and methods of using same

A pharmaceutical composition for eliciting an onset hastened analgesic and anti-inflammatory response and combating nausea in acute migraine attacks comprising more than one active ingredient, wherein said more than one active ingredient consist essentially of:

• (i) domperidone or an analogue thereof in an amount sufficient to hasten the onset of the analgesic and anti-inflammatory response and to combat nausea in an acute migraine attack,
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic add, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and soxicam;
• and
• (iii) a narcotic analgesic, or a pharmaceutically acceptable salt thereof or a pure (−) or pure (+) optical isomer thereof in an analgesically effective amount.

A method for eliciting an onset hastened analgesic and anti-inflammatory response in acute migraine attacks in a subject in need of the analgesic and anti-inflammatory response, comprising administering a pharmaceutical composition comprising effective amounts of more than one active ingredient to said subject, wherein said more than one active ingredient consist essentially of:

• (i) domperidone or an analogue thereof in an amount sufficient to hasten the onset of the analgesic and anti-inflammatory response in an acute migraine attack,
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam;
• and
• (iii) a narcotic analgesic, or a pharmaceutically acceptable salt thereof or a pure (−) or (+) pure optical isomer thereof in an analgesically effective amount.

A pharmaceutical composition for eliciting an onset hastened analgesic and anti-inflammatory response in acute migraine attacks comprising effective amounts of more than one active ingredient to said subject, wherein said more than one active ingredient consist essentially of:

• (i) domperidone or an analogue thereof in an amount sufficient to hasten the onset of the analgesic and anti-inflammatory response in an acute migraine attack,
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclotenac, ibufenac, isoxopac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam;
• and
• (iii) a narcotic analgesic, or a pharmaceutically acceptable salt thereof or a pure (−) or (+) pure optical isomer thereof in an analgesically effective amount.

A method for combating nausea in acute migraine attacks in a subject in need of an anti-nausea response, comprising administering a pharmaceutical composition comprising more than one active ingredient to said subject, wherein said more than one active ingredient consist of:

• (i) domperidone or an analogue thereof in an amount sufficient to combat nausea in an acute migraine attack,
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam;
• and
• (iii) a narcotic analgesic or a pharmaceutically acceptable salt thereof, or a pure (−) or pure (+) optical isomer thereof in an analgesically effective amount.

A method for combating nausea in acute migraine attacks in a subject in need of an anti-nausea response, comprising administering a pharmaceutical composition comprising more than one active ingredient to said subject, wherein said more than one active ingredient consist of:

• (i) domperidone or an analogue thereof in an amount sufficient to combat nausea in an acute migraine attack;
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam;
• and
• (iii) a narcotic analgesic or a pharmaceutically acceptable salt thereof, or a pure (−) or pure (+) optical isomer thereof in an analgesically effective amount.

A pharmaceutical composition for combating nausea in acute migraine attacks, comprising more than one active ingredient, wherein said more than one active ingredient consist of:

• (i) domperidone or an analogue thereof in an amount sufficient to combat nausea in an acute migraine attack,
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and ant-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, tentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam, fenamic acid derivatives, biphenylcarboxylic acid derivatives and oxicams;
• and
• (iii) a narcotic analgesic or a pharmaceutically acceptable salt thereof, or a pure (−) or pure (+) optical isomer thereof in an analgesically affective amount.

A pharmaceutical composition for combating nausea in acute migraine attacks, comprising more than one active ingredient, wherein said more than one active ingredient consist of:

• (i) domperidone or an analogue thereof in an amount sufficient to combat nausea in an acute migraine attack;
• (ii) a NSAID, a pharmaceutically acceptable salt thereof or a pure (−) or (+) optical isomeric form thereof in an analgesically and anti-inflammatory effective amount, wherein said NSAID is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, prapoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxipinac, mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid, tolfenamic acid, diflunisal, flufenisal, piroxicam, sudoxicam and isoxicam;
• and
• (iii) a narcotic analgesic, a pharmaceutically acceptable salt thereof or a pure (−) or pure (+) optical isomer thereof in an analgesically effective amount.