Implants for controlled release of pharmaceutically active principles and method for making same

A process for the preparation of an implant for the controlled release of at least one pharmaceutically active principle, wherein:

• a core containing at least one active principle is produced,
• at least one polymeric film of controlled thickness is prepared before application to the core,
• the polymeric film(s) is/are applied around said core by juxtaposing and superposing it/them,
• the implant thus obtained is sterilized,
• wherein the polymeric film of the sheath is composed of a mixture, in proportions in the range 40:60 to 60:40, of a poly(lactide-co-glycolide) acid having a molecular weight which is in the range 20,000 daltons to 100,000 daltons, and a polylactide acid polymer, which is a polyester derived from an α-hydroxycarboxylic acid, having a molecular weight in the range 2,000 daltons to 6,000 daltons.

A process for the preparation of an implant for the controlled release of at least one pharmaceutically active principle, wherein:

• a core containing at least one active principle is produced,
• at least one polymeric film of controlled thickness is prepared before application to the core,
• the polymeric film(s) is/are applied around said core by juxtaposing it/them,
• the implant thus obtained is sterilized,
• wherein the polymeric film of the sheath is composed of a mixture, in proportions in the range 40:60 to 60:40, of a poly(lactide-co-glycolide) acid having a molecular weight which is in the range 20,000 daltons to 100,000 daltons, and a polylactide acid polymer, which is a polyester derived from an α-hydroxycarboxylic acid, having a molecular weight in the range 2,000 daltons to 6,000 daltons.

A process for the preparation of an implant for the controlled release of at least one pharmaceutically active principle, wherein:

• a core containing at least one active principle is produced,
• at least one polymeric film of controlled thickness is prepared before application to the core,
• the polymeric film(s) is/are applied around said core by superposing it/them,
• the implant thus obtained is sterilized,
• wherein the polymeric film of the sheath is composed of a mixture, in proportions in the range 40:60 to 60:40, of a poly(lactide-co-glycolide) acid, having a molecular weight which is in the range 20,000 daltons to 100,000 daltons, and a polylactide acid polymer, which is a polyester derived from an α-hydroxycarboxylic acid, having a molecular weight in the range 2,000 daltons to 6,000 daltons.