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US 6,319,501 B1Granted
Method of immunizing against hepatitis B virus
AssigneeHealth Research, Inc.
InventorsAlexander Robert Neurath, Nathan Strick, Yasmin M. Thanavala, Michael W. Pride
Life of this patent
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Abstract
A method for immunizing a human against hepatitis B virus comprising administering to the human a vaccine comprising a hepatitis B virus surface antigen, wherein included in the vaccine is one or more antigens of non-permitted variant sequences within residues S(139-147) of the hepatitis B virus surface antigen.
Claims2
A vaccine comprising a hepatitis B virus surface antigen having the sequence (CTKPSDGNC) within residues S(139-147) and at least one non-permitted variant of said surface antigen where at least one of the following substitutions in S(139-147) is made:
- at 141 K is substituted with D, E or R
- at 142 P is substituted with S
- at 143 T(S) is substituted with G, D, E, R, K or M
- at 144 D is substituted with G, A, S, R, K, T, N or E
- at 145 G is substituted with A, S, D, R or K;
- and
- at 146 N is substituted with G, A, S, R, K or D said vaccine being essentially free of permitted variants of hepatitis B virus surface antigen having the sequence (CTKPSDGNC) within residues S(139-147).
4 more elements
Dependencies are inferred from the claim text.