Method for producing small-particle preparations of biologically active substances
AssigneeBASF SE
InventorsJörg Breitenbach, Hans Dieter Zettler
Life of this patent
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Abstract
A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder divided into a plurality of zones, wherein there is firstly melting of the matrix auxiliaries and mixing of the bioactive components with the matrix auxiliaries in a heatable zone, after which the mixture is cooled, precomminuted and finely ground in a cooling zone, the screw geometry in the cooling zone being selected so that the cooling zone consists of a conveying zone, a mixing zone and a kneading zone.
Claims17
A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder having an extruder jacket, which extruder is divided into a plurality of zones, wherein the process comprises
- firstly melting the matrix auxiliaries and mixing the bioactive components with the matrix auxiliaries in a heatable zone of the extruder to form a mixture, and
- subsequently cooling, precomminuting and finely grinding the mixture in a cooling zone of the extruder to form a powder,
- wherein the screw geometry in the cooling zone is selected so that the cooling zone has a conveying zone as first zone, followed by a mixing zone and/or a kneading zone.
An arrangement for carrying out a process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, which arrangement consists of a mixing unit and a collecting unit, where the mixing unit and the collecting unit are connected together to form a system which is closed to the outside, and wherein the mixing unit consists of an extruder which has heatable and coolable zones and which has a discharge opening for feeding the extruder discharge into the collecting unit by means of conveying elements, and which collecting unit consists of a cylindrical container provided with a conical discharge funnel.
An arrangement for carrying out a process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, which arrangement consists of a mixing unit and a collecting unit, where the mixing unit and the collecting unit are connected together to form a system which is closed to the outside, and wherein the mixing unit consists of an extruder which has heatable and coolable zones and which has a discharge opening for feeding the extruder discharge into the collecting unit by means of conveying elements, and which collecting unit consists of a cylindrical container provided with a conical discharge funnel, and in which the conveying elements at the extruder outlet project beyond the screw channel into the interior of the collecting zone.
Dependencies are inferred from the claim text.