ETM-775 metabolite of ecteinascidin 743
AssigneeThe Board of Trustees of the University of Illinois
InventorsKenneth L. Rinehart, Jose J. Morales, Joel Reid, Isabel Reymundo, Pablo Floriano, Lola Garcia Gravalos
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Abstract
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as “ETM” followed by a numeric value, which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows:
Claims2
Substantially pure ETM-775 having the following structure:
A pharmaceutical composition comprising ETM-775 and a pharmaceutically acceptable carrier, diluent or excipient.
Dependencies are inferred from the claim text.