Gas filled microspheres as magnetic resonance imaging contrast agents
AssigneeImarx Therapeutics, Inc.
InventorEvan C. Unger
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Abstract
Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.
Claims43
A contrast medium for magnetic resonance imaging, said contrast medium comprising gas filled liposomes wherein said liposomes are prepared by a method which comprises the step of agitating an aqueous suspension of a biocompatible lipid in the presence of a gas, at a temperature below the gel to liquid crystalline phase transition temperature of the biocompatible lipid, until gas filled liposomes result, wherein said gas is hyperpolarized rubidium entriched xenon.
A method of preparing gas filed liposomes for use as a magnetic resonance imaging contrast medium, said method comprising the step of agitating an aqueous suspension of a biocompatible lipid in the presence of a gas, at a temperature below the gel to liquid crystalline phase transition temperature of the biocompatible lipid, unitl said gas filled liposomes result, wherein said gas is hyperpolarized rubidium enriched xenon.
Dependencies are inferred from the claim text.