Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion

A compound of formula I,

• wherein:
• R1 and R2 independently of one another are hydrogen or (C1-C6)-alkyl which is unsubstituted or substituted by R3, or in which the radicals R1— and R2— together are a saturated or unsaturated bivalent (C2-C9)-alkylene radical which is unsubstituted or is substituted by one or more groups from the group consisting of halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C6)-alkyl-, (C5-C14) -heteroaryl, (C5-C14)-heteroaryl-(C1-C6)-alkyl-, (C3-C12)-cycloalkyl, (C3-C12)-cycloalkyl-(C1-C6)-alkyl- and oxo, where a 5-membered to 7-membered saturated or unsaturated ring which is unsubstituted or is substituted by R3 and which is a carbocyclic ring or a heterocyclic ring containing one or two ring nitrogen atoms, can be fused to a carbon-carbon bond in the (C2-C9)-alkylene radical;
• R3 is (C1-C8)-alkyl, (C1-C8)-alkoxy, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C4)-alkyl-, (C5-C14)-heteroaryl, (C5-C14)-heteroaryl-(C1-C4)-alkyl-, halogen, trifluoromethyl, hydroxyl, oxo, nitro, amino, —NH—(C1-C4)-alkyl, —N((C1-C4)-alkyl)2, —NH—CO—(C1-C4)-alkyl, or —CO—(C1-C4)-alkyl;
• R4 is hydrogen, (C1-C6)-alkyl-CO—O—(C1-C4)-alkyl- or (C1-C6)-alkyl which is unsubstituted or is substituted by a radical selected from the group consisting of hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl-S(O)2—, —NR7R7′ and —N+R7R7′R7″Q−, where R7, R7′ and R7″ independently of one another are hydrogen, (C1-C6)-alkyl, (C5-C14)-aryl or (C5-C14)-aryl-(C1-C6)-alkyl- and Q− is a physiologically tolerable anion, or in which R4 is one of the radicals
• in which the bonds, via which the radicals are bonded, are indicated by dashed lines;
• R5 is (C1-C20)-alkyl, (C5-C20)-monocycloalkyl, (C5-C20) -bicycloalkyl, (C5-C20)-tricycloalkyl, (C6-C14)-aryl, (C5-C14)-heteroaryl, (C6-C14)-aryl-(C1-C6)-alkyl- or (C5-C14)-heteroaryl-(C1-C6)-alkyl-, wherein one or more carbon atoms of the alkyl radical, the monocycloalkyl radical, the bicycloalkyl radical and the tricycloalkyl radical is optionally replaced by identical or different atoms selected from the group consisting of nitrogen, oxygen and sulfur, and wherein the aryl radical, the heteroaryl radical, the alkyl radical, the monocycloalkyl radical, the bicycloalkyl radical and the tricycloalkyl radical each is unsubstituted or is substituted by one, two or three radicals R3;
• and
• R6 is hydrogen, (C1-C6)-alkyl-O—CO—, hydroxyl, (C1-C6)-alkyl-O—CO—O— or nitro;
• in all its stereoisomeric forms and mixtures thereof in all ratios, and its physiologically tolerable salts and prodrugs.