Genetically engineered glutaminase and its use in antiviral and anticancer therapy
AssigneeME Medical Enzymes AG
InventorsJoseph Roberts, Thomas W MacAllister, Natarajan Sethuraman, Abbie G. Freeman
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Abstract
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent anti-cancer agent. The glutaminase of the present invention is particularly useful for treating lung, breast and colon cancer cells and in the treatment of HIV-infected cells.
Claims17
An E. coli cell which comprises a gene that encodes a therapeutically suitable glutaminase.
An isolated and purified DNA molecule comprising a nucleotide sequence coding for a therapeutically suitable glutaminase.
Dependencies are inferred from the claim text.