Rapid gelling biocompatible polymer composition
AssigneeCohesion Technologies, Inc.
InventorsDonald G. Wallace, Gregory M. Cruise, Woonza M. Rhee, Jacqueline Anne Schroeder, George T. Coker, III, Marcee M. Maroney
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Abstract
This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, they are useful as tissue sealants, in promoting hemostasis, for drug delivery, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.
Claims40
A biocompatible gel-forming composition for in vivo administration, comprising:
- a first component comprising at least one sulfhydryl group-containing compound in a liquid medium having an alkaline pH, wherein said sulfhydryl group-containing compound is given by the formula Compound1-(SH)m, wherein m≧2;
- and
- a second component comprising at least one sulfhydryl reactive group-containing compound in either a liquid medium having a neutral or acidic pH or in powder form, wherein said sulfhydryl reactive group-containing compound is given by the formula Compound2-Yn, wherein Y is a sulfhydryl reactive group and wherein n≧2;
- wherein at least one of the first or second components is a polyalkylene oxide and wherein the sulfhydryl groups and the sulfhydryl reactive groups react with one another to form covalent bonds therebetween when said components are mixed together to form a gel in less than one minute.
A method for treating tissues, comprising the steps of:
- administering to a tissue site a first component comprising at least one sulfhydryl group-containing compound in liquid medium having an alkaline pH, wherein said sulfhydryl group-containing compound is given by the formula Compound1-(SH)m, wherein m≧2;
- and
- simultaneously or subsequently administering to the tissue site a second component comprising at least one sulfhydryl reactive group-containing compound either a liquid medium having a neutral or acidic pH or in powder form, wherein said sulfhydryl reactive group-containing compound is given by the formula Compound2-Yn, wherein Y is a sulfhydryl reactive group and wherein n≧2, and wherein at least one of the first or second components is a polyalkylene oxide;
- and
- allowing the sulfhydryl groups and the sulfhydryl reactive groups to react with one another to form covalent bonds therebetween to form a gel in less than one minute.
A biocompatible gel-forming composition for in vivo administration with a gel time of less than one minute, comprising:
- polyalkylene oxide-(SH)4 in a liquid medium having a pH of between 8 and 10.5;
- and
- polyalkylene oxide-Y4, wherein Y is succinimidyl, in a liquid medium having an acidic pH.
A biocompatible gel-forming composition for in vivo administration with a gel time of less than one minute, comprising:
- polyalkylene oxide-(SH)12 in a liquid medium having an alkaline pH;
- and
- polyalkylene oxide-Y12 in a liquid medium having an acidic pH, wherein Y is a succinimidyl or maleimidyl group.
A biocompatible gel-forming composition for in vivo administration, comprising:
- a sulfhydryl group-containing polyalkylene oxide in a liquid medium having an acidic pH, wherein said sulfhydryl group-containing polyalkylene oxide is given by the formula Core-(SH)m, wherein m≧2;
- and
- a buffer solution with an alkaline pH;
- wherein the sulfhydryl groups react with one another to form covalent bonds therebetween when said components are mixed together to form a gel in less than one minute.
A biocompatible gel-forming composition for in vivo administration, comprising:
- at least one sulfhydryl group-containing compound in a liquid medium having an alkaline pH, wherein said sulfhydryl group-containing compound is given by the formula Compound1-(SH)m, wherein m≧2;
- at least one sulfhydryl reactive group-containing compound either a liquid medium having a neutral or acidic pH or in powder form, wherein said sulfhydryl reactive group-containing compound is given by the formula Compound2-Yn, wherein Y is a sulfhydryl reactive group and wherein n≧2;
- and
- collagen;
- wherein at least one of either the sulfhydryl group-containing compound or the sulfhydryl reactive group-containing compound is a polyalkylene oxide, and wherein the sulfhydryl groups and the sulfhydryl reactive groups are capable of reacting with one another to form covalent bonds therebetween.
A biocompatible gel-forming composition for in vivo administration, comprising:
- (a) a first component in a liquid medium having an acidic pH comprising:
- (i) at least one sulfhydryl group-containing compound given by the formula Compound1-(SH)m, wherein m≧2;
- (ii) at least one sulfhydryl reactive group-containing compound given by the formula Compound2-Yn, wherein Y is a sulfhydryl reactive group and wherein n≧2;
- and
- (iii) collagen;
- and
- (b) a second component comprising a buffer having a pH of between 8 and 10.5;
- wherein at least one of either the sulfhydryl group containing compound or the sulfhydryl reactive group containing compound is a polyalkylene oxide.
Dependencies are inferred from the claim text.