Equine infectious anemia virus vectors
AssigneeOxford Biomedica (UK) Limited
InventorsAlan John Kingsman, Miles William Carroll, Jonathan Rohll, Kyriacos Mitrophanous, Narry Kim
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Abstract
A retroviral vector derived from a non-primate lentivirus genome comprising a deleted gag gene wherein the deletion in gag removes one or more nucleotides downstream of nucleotide 350 of the gag coding sequence.
Claims64
An equine infectious anemia virus (EIAV) vector comprising a gag gene nucleotide coding sequence that is modified so as to contain a deletion located at least 354 nucleotides downstream from the ATG initiation codon of the gag gene in EIAV.
An isolated equine infectious anemia virus (EIAV)-based vector particle comprising functionally active gag-pol proteins, and further comprising a nucleic acid sequence of EIAV gag nucleotide residues having a deletion located at least 350 nucleotides downstream from the ATG initiation codon of the EIAV gag coding sequence.
An equine infectious anemia virus (EIAV)-based retroviral vector particle comprising a gag gene nucleotide coding sequence that is modified so as to contain a deletion located at least 354 nucleotides downstream from the ATG initiation codon of the gag gene in EIAV.
Dependencies are inferred from the claim text.