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US 6,310,267 B1Granted
Flexible wound covering based on fibrin and process for its production
AssigneeAventis Behring GmbH
InventorMirna Rapp
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Abstract
A biodegradable, flexible wound covering based on fibrin and a process for its preparation are described, in which a fibrinogen solution is subjected to a single-stage or multistage dialysis, then a flexible fibrin web is formed by action of an aqueous thrombin solution on the fibrinogen solution and this is subsequently subjected to freeze-drying.
Claims18
A process for the production of a flexible wound covering based on fibrin, comprising:
- subjecting a fibrinogen solution to a single-stage or multistage dialysis,
- forming a flexible fibrin web by action of an aqueous thrombin solution on the fibrinogen solution, and
- freeze-drying the flexible fibrin web,
- wherein the fibrinogen solution is dialyzed in one stage with a solution containing a complexing agent and a physiologically compatible inorganic salt, and
- wherein the complexing agent is an aqueous solution of an alkali metal salt selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), of oxalic acid or, of citric acid.
2 more elements
Dependencies are inferred from the claim text.