Form a of fluoxetine hydrochloride

A process for preparing Form A of fluoxetine hydrochloride in pure form wherein said Form A is characterized by having an x-ray powder diffraction pattern consistent with fluoxetine hydrochloride, and further characterized by having a single endotherm as determined by differential scanning calorimetry run at a maximum rate of 1° C. per minute, said process comprising crystallizing said Form A by providing sufficient compression to convert fluoxetine hydrochloride to said Form A of fluoxetine hydrochloride.

A process for preparing Form A of fluoxetine hydrochloride in pure form wherein said Form A is characterized by the following single crystallographic parameters:

• crystal class orthorhombic space group Pbca (#61) a (Å) 10.3754 (4) b (Å) 10.4603 (2) c (Å) 32.3412 (12) V (Å) 3510.0 (3) d calc (g/cm3) 1.31 R, RW 0.038, 0.038,
• said process comprising crystallizing said Form A by providing sufficient compression to convert fluoxetine hydrochloride to said Form A of fluoxetine hydrochloride.

A process for preparing Form A of fluoxetine hydrochloride in essentially pure form comprising crystallizing said Form A by providing sufficient compression to convert fluoxetine hydrochloride to said Form A of fluoxetine hydrochloride.

A process for preparing Form A of fluoxetine hydrochloride wherein said Form A is characterized by having an x-ray powder diffraction pattern consistent with fluoxetine hydrochloride, and further characterized by having at least two endotherms as determined by differential scanning calorimetry run at a maximum rate of 1° C. per minute, provided that the amount of fluoxetine hydrochloride polymorphs other than Form A does not exceed an amount greater than about 10 percent (w/w), said process comprising crystallizing said Form A by providing sufficient compression to convert fluoxetine hydrochloride to said Form A of fluoxetine hydrochloride.

A process for preparing Form A of fluoxetine hydrochloride wherein said Form A is characterized by having an x-ray powder diffraction pattern consistent with fluoxetine hydrochloride, and further characterized by having at least two endotherms as determined by differential scanning calorimetry run at a maximum rate of 1° C. per minute, provided that the amount of fluoxetine hydrochloride polymorphs other than Form A does not exceed an amount greater than about 5 percent (w/w), said process comprising crystallizing said Form A by providing sufficient compression to convert fluoxetine hydrochloride to said Form A of fluoxetine hydrochloride.