Form A of fluoxetine hydrochloride
OwnerGrayson Walker Stowell, Robert R. Whittleinventors
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Abstract
The present invention provides novel amorphous fluoxetine hydrochloride as a useful intermediate for the preparation of Form A of fluoxetine hydrochloride.
Claims5
Amorphous fluoxetine hydrochloride.
Fluoxetine hydrochloride consisting essentially of amorphous fluoxetine hydrochloride.
A process for preparing amorphous fluoxetine hydrochloride comprising heating substantially crystalline fluoxetine hydrochloride past the melting point thereof until melted fluoxetine hydrochloride is formed, and cooling said melted fluoxetine hydrochloride under conditions which yield said amorphous fluoxetine hydrochloride.
A process for preparing Form A of fluoxetine hydrochloride comprising heating substantially crystalline fluoxetine hydrochloride past the melting point thereof until melted fluoxetine hydrochloride is formed, cooling said melted fluoxetine hydrochloride under conditions which yield amorphous fluoxetine hydrochloride, and nucleating said amorphous fluoxetine hydrochloride to initiate transformation to said Form A of fluoxetine hydrochloride.
Dependencies are inferred from the claim text.