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US 6,310,247 B1Granted
7-aryl-6(Z)-heptatrienoic acid retinamides
AssigneeHoffmann-La Roche Inc.
InventorsAdrian Wai-Hing Cheung, Stephen B. Ferguson, Louise Helen Foley, Allen John Lovey
Life of this patent
Estimating the term…
Abstract
Novel trienoic retinoid compounds of with apoptotic activity useful for the prevention and treatment of cancer.
Claims32
A compound of formula
- wherein R1 and R2 are independently hydrogen, halogen, alkyl, alkoxy, or trihalomethyl;
- R3 is hydrogen or alkyl;
- and R4 is H except when R3 is alkyl then R4 may be alkyl;
- R5, R6, and R8 and R9 are independently halogen, hydrogen, hydroxy, alkyl or alkoxy;
- and R7 is hydrogen or alkyl;
- which is free of 6-trans isomers.
3 more elements
Dependencies are inferred from the claim text.