Acylpyrroledicarboxylic acids and acylindoledicarboxylic acids and their derivatives as inhibitors of cytosolic phospholipase A2

A substituted pyrrole compound or a substituted indole compound of the formulae I and II:

• in which
• R1 is a radical —Y1—Ar—Y2—Y3 where Y1 is a C1-C12-alkyl, C2-C12-alkenyl, C1-C12-alkoxy or C2-C12-alkenyloxy radical which is uninterrupted or interrupted by one or more oxygen atoms, Ar, is an aryl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group of R6, R7 and R8, Y2 is a C1-C12-alkyl, C2-C12-alkenyl, C1-C12-alkoxy or C2-C12-alkenyloxy radical which is uninterrupted or interrupted by one or more oxygen atoms, and Y3 is —COOR17, —CONR17R17, —CONHCOR19, —CONHS(O)2R19, —CONHNHS(O)2R19, or —Tz where Tz is 1H- or 2H-tetrazol-5-yl;
• R2 is —COOR17, —Y4—COOR17, —CONR17R17, —Y4—Y4—CONR17R17, —CONHCOR19, —Y4—CONHCOR19, —CONHS(O)2R19, —Y4—CONHS(O)2R19, —CONHNS(O)2R19, —Y4—CONHNHS(O)2R19, —Tz or —Y4—Tz where Y4 is a C1-C8-alkyl or C2-C8-alkenyl group which is uninterrupted or interrupted by an oxygen atom, and Tz is 1H- or 2H-tetrazol-5-yl;R3 is —CO—R9 where R9 is —Y5, -aryl or —Y5-aryl, where Y5 is a C1-C19-alkyl, C2-C19-alkenyl or -alkynyl group which is uninterrupted or interrupted by one or more oxygen atoms and aryl is an aryl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group of R10, R11 and R12;
• each R4 radical is, independently of the others, a hydrogen atom, a halogen atom, —CF3, —Y6, -aryl or —Y6-aryl, where Y6 is a C1-C8-alkyl or C2-C8-alkenyl or -alkynyl group which is uninterrupted or interrupted by one or more oxygen atoms, and aryl is an aryl group which is unsubstituted or substituted by 1 to 3 substituents selected from the group of R13, R14 and R15, and n is the number 2;
• and where two Y6 radicals can, if they are two adjacent alkyl radicals, form together with the carbon atom to which they are bonded a 5-8-membered ring which is unsubstituted or substituted by 1 to 2 C1-C4-alkyl groups;
• each
• R5 radical is, independently of the others, a hydrogen atom or R16, and m is the number 4;
• R6, R7, R8, R10, R11, R12, R13, R14, R15 and R16 are selected independently of one another from:
• (1) a C1-C20-alkyl group which is uninterrupted or interrupted by an oxygen atom;
• (2) a C2-C20-alkenyl group which is uninterrupted or interrupted by an oxygen atom;
• (3) a C2-C20-alkynyl group which is uninterrupted or interrupted by an oxygen atom;
• (4) halogen;
• (5) —CF3;
• (6) perhalo-C1-C6-alkenyl;
• (7) —CN;
• (8) —NO2;
• (9) —OR17;
• (10) —SR17;
• (11) —COOR17;
• (12) —COR18;
• (13) —COCH2OH;
• (14) —NHCOR17;
• (15) —NR17R17;
• (16) —NHS(O)2R17;
• (17) —SOR17;
• (18) —S(O)2R17;
• (19) —CONR17R17;
• (20) —SO2NR17R17;
• (21) —OOCR18;
• (22) —OOCNR17R17;
• (23) —OOCOR17;
• (24) —(CH2)rOR23;
• (25) —(CH2)rSR23;
• (26) —(CH2)rNHR23;
• (27) —(CH2)sR20;
• R17 is in each case, independently of one another, hydrogen, a C1-C20-alkyl or C2-C19-alkenyl or -alkynyl group which is uninterrupted or interrupted by an oxygen atom or —(CH2)tR20;
• R18 is in each case, independently of one another, R17, —CF3, —(CH2)uCOOH or —(CH2)uCOO R21;
• R19 is in each case, in dependently of one another, R17 or —CF3;
• R20 is in each case, independently of one another, aryl substituted by one or two R22 groups;
• R21 is in each case, independently of one another, C1-C6-alkyl, benzyl or phenyl;
• R22 is in each case, independently of one another, hydrogen, halogen, C1-C12-alkyl, C1-C12-alkoxy, C1-C12-alkylthio, C1-C12-alkylsulfonyl, C1-C12-alkylcarbonyl, —CF3, —CN or —NO2;
• R23 is in each case, independently of one another, hydrogen or —COR21;
• r is 1 to 20;
• s and t are, in each case, independently of one another, 0 to 12;
• u is 0 to 4;
• or the pharmaceutically suitable salts or esters thereof.