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US 6,310,210 B1Granted
Camptothecin derivatives
AssigneeKabushiki Kaisha Yakult Honsha
InventorsTakanori Ogawa, Takashi Yaegashi, Seigo Sawada, Tomio Furuta
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Abstract
The present invention relates to new camptothecin derivatives shown by the below formula, which are water-soluble and excellent in an anti-tumor activity, and to salts thereof. In the formula, R1 represents a hydrogen atom or an alkyl group with 1-6 carbon atoms, R2 represents identically or differently 0-4 alkyl groups with 1-6 carbon atoms, a halogen atom, an alkoxyl or hydroxyl group, R3 represents a lower alkylamino, di-lower alkylamino, arylamino, cyclicamino or lower alkoxyl group, and salts thereof.
Claims1
Camptothecin derivatives of the general formula (1)
- wherein R1represents a hydrogen atom or an alkyl group with 1-6 carbon atoms,
- R2 represents identically or differently 0-4 alkyl groups with
- 1-6 carbon atoms, a halogen atom, an alkoxyl or hydroxyl group,
- R3 represents a lower alkylamino, di-lower alkylamino, arylamino, cyclicamino or lower alkoxyl group, and pharmaceutically acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.