Nitric oxide carriers based on polyazamacrocycle complexes

Abstract

Novel compounds capable of carrying and releasing nitrogen oxide (NO) in a biological medium, their use for implementing a therapeutic treatment method or a diagnostic method applied to a human or animal body, and for making medicines useful for treating or preventing disorders affecting the human or animal cardiovascular, nervous, immune, renal or pulmonary system, specifically, an organometallic complex of nitrogen oxide, wherein the cationic part is of the formula (I) in which x=0 or 1; x′=2 or 3; y=0, 2 or 3; z=0 or 1; with the condition that, if y=0 (or z=0) then z=0 (or y=0; respectively); R is a group chosen from the group formed by: a hydrogen atom, —(CH2)2COOH and R1, R2, R3 and R4 are groups chosen from the group formed by: a hydrogen atom and alkyl groups comprising from 1 to 4 carbon atoms; and M2+ is a divalent cation Fe++ or Co++.

Dependencies are inferred from the claim text.