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AssigneeNew York University Medical Center
InventorsHaruhiko Kouhara, Taly Spivak-Kroizman, Irit Lax, Joseph Schlessinger
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The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
An isolated, enriched or purified polypeptide, comprising the amino acid sequence set forth in SEQ ID NO:9.
An isolated, enriched, or purified polypeptide, wherein said polypeptide comprises at least 100 contiguous amino acid residues of the amino acid sequence set forth in SEQ ID NO:9.
An isolated, enriched or purified polypeptide, comprising an amino acid sequence that:
An isolated, enriched or purified polypeptide, comprising an amino acid sequence that differs from the sequence set forth in SEQ ID NO:9 in that it lacks at least one, but not all, of the domains selected from the group consisting of a myristylation region, a phosphotyrosine binding domain and a C-terminal region.
Dependencies are inferred from the claim text.