S(−)-tolterodine in the treatment of urinary and gastrointestinal disorders
AssigneeBridge Pharma, Inc.
InventorGunnar Aberg
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Abstract
The S-isomer of a compound represented by the following formula: and pharmaceutically acceptable salts thereof is disclosed as being useful for treating urinary disorders, including urinary incontinence, and gastrointestinal disorders, including gastrointestinal hyperativity.
Claims12
A method for treating urinary incontinence incontinence, while reducing concomitant liability of adverse effects associated with racemic tolterodine or the R-enantiomer of tolterodine, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of S(−)-2-[α-[2-(diisopropylamino)ethyl]benzyl]-p-cresol or a, pharmaceutically acceptable salt thereof, substantially free of its R enantiomer.
A method for treating gastrointestinal hyperactivity, while reducing concomitant liability of adverse effects associated with racemic tolterodine or the R-enantiomer of tolterodine, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of S(−)-2-[α-[2-(diisopropylamino)ethyl]benzyl]-p-cresol or a pharmaceutically acceptable salt thereof, substantially free of its R enantiomer.
Dependencies are inferred from the claim text.