Pharmaceutical compositions and methods for use
AssigneeTargacept, Inc.
InventorsGary Maurice Dull, Jared Miller Wagner, William Scott Caldwell, Craig Harrison Miller, Jeffrey Daniel Schmitt, Balwinder Singh Bhatti, Srishailkumar Basawannappa Hadimani
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (E)-4-(3-aminophenyl)-3-buten-1-amine, (E)-N-methyl-4-(3-aminophenyl)-3-buten-1-amine and (E)-N-methyl-5-(3-aminophenyl)-4-penten-2-amine.
Claims9
A compound having the formula:
- where AIV is OR″ or NO2;
- A, AI, AII and AIII are substituent species characterized as having a sigma m value between about −0.3 and about 0.75;
- EI, EII, EIII, R′, R″, Z and ZI are individually hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- and the wavy line in the structure indicates that the compound can have the cis (Z) or tans (E) form.
A pharmaceutical composition incorporating a compound having the formula:
- where AIV is OR″ or NO2;
- A, AI, AII and AIII are substituent species characterized as having a sigma m value between about −0.3 and about 0.75;
- EI, EII, EIII, R′, R″, Z and ZI are individually hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- and the wavy line in the structure indicates that the compound can have the cis (Z) or tans (E) form.
A method for treating a central nervous system disorder characterized by an alteration in normal neurotransmitter release comprising administering to a subject in need thereof, an effective amount of a compound of the formula:
- where AIV is OR″ or NO2;
- A, AI, AII and AIII are substituent species characterized as having a sigma m value between about −0.3 and about 0.75;
- EI, EII, EIII, R′, R″, Z and ZI are individually hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- and the wavy line in the structure indicates that the compound can have the cis (Z) or tans (E) form.
Dependencies are inferred from the claim text.