Fungicidal saponin, CAY-1, and isolation thereof from Capsium species fruit
AssigneesThe United States of America as represented by the Secretary of Agriculture, Mycologics, Inc.
InventorsAnthony J. De Lucca, II, John M. Bland, Craig B. Vigo, Claude P. Selitrennikoff
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Abstract
A novel antifungal compound, “CAY-1”, was isolated from the dried fruit of Capsicum frutescens (cayenne pepper), purified to homogeneity, and characterized as a novel sterol glycoside (a saponin) with a molecular mass of 1243.35 Da. CAY-1 demonstrates antifungal activity against a large variety of fungal organisms associated with diseases in plants, animals and humans including, but not limited to, Aspergillus flavus, A. fumigatus, A. parasiticus, A. niger, Pneumocystis carnii and Candida albicans, but has minimal toxic effects on mammalian cells.
Claims15
An isolated compound having the following formula:
An antifungal composition comprising:
- (1) a compound having the following formula:
- (2) a carrier or vehicle for said compound, wherein said compound is present in an amount effective to inhibit the growth of a fungal organism.
A method for inhibiting the growth of a fungal organism comprising the step of applying to a substrate susceptible to inoculation with said fungal organism a compound having the following formula:
- wherein said compound is in an amount effective to inhibit said growth.
Dependencies are inferred from the claim text.