Composition for the administration of a D1-agonists

A method for treating a patient in need of treatment with a full or partial D1-agonist, the method comprising administering intranasally a composition in the form of a powder or microspheres comprising a full or partial D1-agonist of the dopamine receptor wherein the full or partial D1-agonist of the dopamine is taken up by mucosal absorption.

A method for preparing a pharmaceutical composition comprising a drug, the method comprising

• (a) making an oil-in-water emulsion in which the drug is located in the oil phase, wherein the emulsion is stabilised by the use of a copolymer of acrylic acid and methacrylic acid esters;
• and
• (b) spray drying the emulsion.

A device for administering a full or partial D1-agonist to a patient comprising

• a nasal administration device having a composition in the form of a powder or microspheres comprising a full or partial D1-agonist of the dopamine receptor wherein the full or partial D1-agonist of the dopamine is taken up by mucosal absorption.

A method of delivering a full or partial D1-agonist to a patient comprising

• administering intranasally to the patient a composition in the form of a powder or microspheres comprising a full or partial D1-agonist of the dopamine receptor wherein the full or partial D1-agonist of the dopamine is taken up by mucosal absorption.