Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
AssigneeAllergan Sales, Inc.
InventorRobert M. Burk
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Abstract
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: wherein wavy line attachments indicate either the alpha (α) or beta (μ) configuration; dashed bonds represent a double bond, or a single bond, R is a substituted heteroaryl radical, R1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of —OR1 and —N(R1)2, Y is =O or represents 2 hydrogen radicals. Certain of the compounds represented by Formula I comprise another aspect of the present invention.
Claims26
A method of treating gastric or duodenal ulcer, osteoporosis, constipation, renal disorders, sexual dysfunction, baldness, diabetes, cancer and disorder of immune regulation which comprises administering to a mammal having said disease a therapeutically effective amount of a compound represented by formula I:
- wherein the hatched segments represent α bonds, the solid triangle represents aβ bond, wavy line attachments indicate either the alpha (α) or beta (β) configuration;
- dashed bonds represent a double bond or a single bond, R is a substituted hetero aryl radical, R1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of —OR1 and —N(R1)2, Y is =O or represents 2 hydrogen radicals.
Dependencies are inferred from the claim text.