Substituted dimeric compounds

A compound selected from those of formula (I):

• A—G1—Cy—G2—Cy′—G3—B (I)
• wherein:
• A represents a grouping of formula
• wherein:
• Q represents sulphur or oxygen,
• R1, R2, and R3 which may be identical or different, represent hydrogen or Ra, wherein Ra represents unsubstituted or substituted linear or branched (C1-C6)alkyl, unsubstituted or substituted linear or branched (C2-C6)alkenyl, unsubstituted or substituted linear or branched (C2-C6)alkynyl, unsubstituted or substituted (C3-C8)-cycloalkyl, unsubstituted or substituted cycloalkyl-(C3-C8)alkyl in which the alkyl moiety is linear or branched, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, aryl, aryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched, aryl-(C2-C6)alkenyl in which the alkenyl moiety is linear or branched, heteroaryl, heteroaryl-(C1-C6)alkyl in which the alkyl moiety is linear or branched or heteroaryl-(C2-C6)alkenyl in which the alkenyl moiety is linear or branched, or R2 and R3 can also form with the nitrogen atom carrying them a group selected from piperazinyl, piperidinyl and pyrrolidinyl,
• B represents a grouping of formula
• or —NR2R3, wherein Q, R1, R2, and R3 are as defined hereinbefore,
• G1 and G3, which may be identical or different, represent a linear or branched alkylene chain containing 1 to 4 carbon atoms that are optionally substituted by one or more identical or different groups selected from hydroxy, carboxy, formyl, Ra, ORa, COORa and CORa, wherein Ra is as defined hereinbefore,
• Cy and Cy′, which are different, represent
• a ring structure of formula (II):
• wherein:
• X and Y, which may be identical or different, represent sulphur, oxygen or carbon, or CH or CH2,
• R4 represents hydrogen or halogen, or CF3, hydrogen, carboxy, formyl, amino, NHRa, NRaR1a, NHCORa, CONHRa, Ra, ORa, CORa or COORa, wherein Ra is as defined herein before and R1a can have any of the meanings of Ra,
• the symbol means that the bonds are single or double, with the proviso that he valency of the atoms is respected,
• wherein G2 substitutes the benzene ring, and G1 substitutes the ring containing X and Y in the case of Cy, and G2 substitutes the benzene ring and G3 substitutes the ring containing X and Y in the case of Cy′,
• or a ring structure of formula (III):
• wherein:
• Z represents sulphur or oxygen, or CH2, NH, NSO2Ph or NRa wherein Ra is as defined hereinbefore,
• D represents a benzene or pyridine ring,
• R4 is as defined hereinbefore,
• the symbol means that the bond is single or double, with the proviso that the valency of the atoms is respected,
• wherein G2 substitutes the D ring, and G1 substitutes the ring containing Z in the case of Cy, and G2 substitutes the D ring and G3 substitutes the ring containing Z in the case of Cy′,
• the two different rings Cy and Cy′ of the compounds of formula (I) both being represented by a structure of formula (II) or by a structure of formula (III), or one of the two rings being represented by a structure of formula (II) and the other being represented by a structure of formula (III),
• G2 represents a chain of formula (IV):
• wherein:
• W1, W2, and W3, which may be identical or different, represent a bond, oxygen or sulfur, or CH2, CHRa, NH, or NRa, wherein Ra is as defined hereinbefore,
• n represents an integer wherein 0≦n≦6,
• m represents an integer wherein 0≦m≦6,
• with the proviso that it is not possible to have two consecutive hetero atoms and that the chain of formula (IV) so defined may have one or more unsaturated bonds,
• it being understood that:
• “aryl” is naphthyl, phenyl, or biphenyl,
• “heteroaryl” is a saturated or unsaturated mono- or bi-cyclic group containing 5 to 10 ring atoms and containing 1 to 3 hetero atoms selected from nitrogen, sulphur, and oxygen,
• it being possible for “aryl” and “heteroaryl” to be substituted by one or more identical or different radicals selected from hydroxy, carboxy, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)alkyl, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, formyl, cyano, nitro, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• the term “substituted” applied to the terms “alkyl”, “alkenyl”, and “alkynyl” means that those groups are substituted by one or more identical or different radicals selected from hydroxy, linear or branched (C1-C6)alkoxy, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• the term “substituted” applied to the terms “cycloalkyl” and “cycloalkylalkyl” means that the cyclic moiety of those groups is substituted by one or more identical or different radicals selected from hydroxy, linear or branched (C1-C6)alkoxy, polyhalo-(C1-C6)alkyl in which the alkyl moiety is linear or branched, amino, linear or branched (C1-C6)alkylamino, di-(C1-C6)alkylamino in which each alkyl moiety is linear or branched, and halogen,
• its enantiomers and diasterioisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base.