Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists

A compound of the following formula:

• and the salts thereof, wherein
• A is hydrogen, halo, hydroxy, C1-C6 alkyl, halo C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkoxy, oxo, OY wherein Y is a hydroxy protecting group, or absent;
• the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent;
• Ar1 is phenyl optionally substituted by one or more substituents selected from halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy-C1-C4 alkoxy, CF3, carboxy-C1-C4 alkoxy and C1-C4 alkoxy-carbonyl-C1-C4 alkoxy;
• Ar2 is pyrimidyl, optionally substituted by one or more substituents selected from halo, hydroxy, amino, nitro, carboxy, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylamino, di C1-C4 alkylamino, halo C1-C4 alkyl, C1-C4 alkythio and sulfonyl methyl;
• R1 is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or OY wherein Y is a hydroxy protecting group;
• and
• R2 and R3 are independently selected from hydrogen, hydroxy, C1-C7 alkyl optionally substituted by one or more hydroxy or halo, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C7 alkoxy, phenyl optionally substituted by halo, phenyl C1-C7 alkyl, halo substituted phenyl C1-C7 alkyl, and (CH2)nX-R4 wherein n is one or two;
• X is O, NH or S and R4 is C1-C3 alkyl, or
• R2 and R3, together with the nitrogen atom to which they are attached, form a pyrrolidine, piperidine or morpholine ring, optionally substituted by C1-C3 alkyl or halo.