Antisense modulation of amyloid beta protein expression
AssigneeSt. Louis University
InventorVijaya B. Kumar
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Abstract
An antisense compound comprising nucleotides complementary to a nucleic acid sequence coding for amyloid precursor protein (APP), wherein the antisense compound inhibits the expression of an amyloid beta protein (AβP) portion of the amyloid precursor protein coding sequence while permitting the expression of at least a portion of the amyloid precursor protein polynucleotide 5′ to the AβP portion of the amyloid precursor protein coding sequence. Pharmaceutical compositions and formulations containing the compound and methods of using the compound to regulate AβP expression in cells and tissues and to treat disease are also provided.
Claims25
An antisense compound comprising a nucleic acid sequence complementary to a nucleic acid sequence that encodes the amino acids of an amyloid precursor protein corresponding to amino acids 618-621 of SEQ ID NO:4 and which inhibits the expression of an amyloid beta protein (AβP) portion of the amyloid precursor protein coding sequence while permitting the expression of at least a portion of the amyloid precursor protein polynucleotide 5′ to the AβP portion of the amyloid precursor protein sequence.
A recombinant DNA or RNA molecule having a DNA or RNA sequence which, upon transcription, produces an antisense RNA against a nucleic acid encoding an amyloid beta protein, said antisense RNA comprising a nucleic acid segment which specifically hybridizes to the complement of one of the nucleic acid molecules of SEQ ID NO:1 or SEQ ID NO:2.
Dependencies are inferred from the claim text.