Compositions and methods for cancer immunotherapy
AssigneeChiron Corporation
InventorsJack R. Barber, Douglas J. Jolly, James G. Respess
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Abstract
The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
Claims5
A method for inhibiting the growth of a solid tumor in a warm-blooded animal, comprising directly administering to the solid tumor of a warm-blooded animal a retroviral vector construct comprising a promoter sequence in operable linkage with a nucleic acid sequence encoding IL-2, wherein expression of said IL-2 inhibits the growth of said solid tumor.
A method for inhibiting the growth of a solid tumor in a warm-blooded animal, comprising directly administering to the solid tumor of a warm-blooded animal a retroviral vector construct comprising a promoter sequence in operable linkage with a DNA sequence encoding an IL-2/IFN-γ fusion protein, a herein expression of said fusion protein inhibits the growth of said solid tumor.
Dependencies are inferred from the claim text.