Individual calibration of blood glucose for supporting noninvasive self-monitoring blood glucose

A method of calibrating a noninvasive glucose monitor for prospective noninvasive glucose determination, comprising the steps of:

• measuring spectroscopic transflectance readings of a patient's skin using a noninvasive glucose monitor;
• measuring the patient's blood glucose level with an invasive glucose monitor;
• correlating the noninvasive and invasive measurements to form an individual algorithm for the patient;
• spatially adjusting a position of the patient's skin with respect to a probe of the noninvasive glucose monitor while collecting transflectance measurements such that multiple readings are taken over a relatively large area of the patient's skin;
• taking noninvasive and invasive measurements over at least a two-epoch period;
• taking noninvasive and invasive measurements over a plurality of glucose levels in the patient;
• and
• converting the spectroscopic transflectance readings to glucose levels using the individual algorithm.

A method of calibrating a noninvasive glucose monitor for prospective noninvasive glucose determination, comprising the steps of:

• measuring spectroscopic transflectance readings of a patient's skin using a noninvasive glucose monitor;
• measuring the patient's blood glucose level with an invasive glucose monitor;
• correlating the noninvasive and invasive measurements to form an individual algorithm for the patient;
• spatially adjusting a position of the patient's skin with respect to a probe of the noninvasive glucose monitor while collecting transflectance measurements such that multiple readings are taken over relatively large area of the patient's skin;
• taking noninvasive and invasive measurements over at least a two-epoch period;
• taking noninvasive and invasive measurements over a plurality of glucose levels in the patient;
• converting the spectroscopic transflectance readings to glucose levels using the individual algorithm;
• spatially adjusting the position of the patient's skin or the probe by a plurality of dithering movements;
• taking multiple transflectance measurements in a pattern on the patient's skin;
• using the noninvasive and invasive measurements from the first epoch to calibrate the noninvasive monitor;
• and
• using the measurements from the second epoch to determine the patient's glucose level.